Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness
نویسندگان
چکیده
منابع مشابه
Neural Correlates of Wakefulness, Sleep, and General Anesthesia: An Experimental Study in Rat.
BACKGROUND Significant advances have been made in our understanding of subcortical processes related to anesthetic- and sleep-induced unconsciousness, but the associated changes in cortical connectivity and cortical neurochemistry have yet to be fully clarified. METHODS Male Sprague-Dawley rats were instrumented for simultaneous measurement of cortical acetylcholine and electroencephalographi...
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AIMS This study was designed to evaluate the changes in EEG power spectra and EEG coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements--locomotion and sensorimotor gating--and the pharmacokinetics of ketamine and norketamine were also conducted. METHODS Ketamine and norketamine levels in rat sera and brains were analyzed by gas chromatography-mass spectromet...
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General anesthesia (GA) is a reversible drug-induced state of altered arousal required for more than 60,000 surgical procedures each day in the United States alone. Sedation and unconsciousness under GA are associated with stereotyped electrophysiological oscillations that are thought to reflect profound disruptions of activity in neuronal circuits that mediate awareness and cognition. Computat...
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Ketamine (KET) induced blockade of cortical spreading depression (CSD) declines with repeated KET applications in a way suggesting the development of tolerance. Possible mechanism of this process was studied in 31 rats anestheized with pentobarbital. CSD was elicited by injection of 1µl of 5% KCl into cortex at 15 min intervals and monitored by recording the accompanying slow potential waves....
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2015
ISSN: 0007-0912
DOI: 10.1093/bja/aev252